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WebMar 22, 2024 · Understanding Flexeril (Cyclobenzaprine) Flexeril is the brand name for Cyclobenzaprine, a prescription muscle relaxer that is similar to a class of Antidepressant drugs called Tricyclic Antidepressants. The generic form was first approved in 1977 and is sold in both immediate and extended release versions. WebJun 28, 2016 · Furthermore, when used in patients receiving opioid therapy, cyclobenzaprine and other CNS depressants potentiate the risk for opioid-induced respiratory depression. 2 Therefore, it’s important to counsel patients on opioids who present a prescription for cyclobenzaprine, or better yet, call the prescriber and share your …

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